BioMatNet Item: FAIR-CT95-0300 - Development from cyclodextrin derivatives to polymeric materials for selective transport, separation and detection of active substances (utilisation of CDX)

FAIR-CT95-0300
Development from cyclodextrin derivatives to polymeric materials for selective transport, separation and detection of active substances (utilisation of CDX)

Contacts
Further Information

	Type of Project	Shared Cost
	Contract No	FAIR-CT95-0300
	Total Cost	1,554,901 ECU
	EC Contribution	1,100,000 ECU
	Start Date	01/01/96
	Duration	36 Months

Development from cyclodextrin derivatives to polymeric materials for selective transport, separation and detection of active substances (utilisation of CDX)

Objectives

Technical Approach

Despite a large number of scientific investigations only a few applications for cyclodextrins exist. The goal of the proposed research is to develop the basis for new applications of cyclodextrins from readily available functional cyclodextrin derivatives and polymers. It comprises application fields like wastewater decontamination, drug formulation, separation of enantiomers and sensor devices.

Expected Results

I. Direct Results

Realisation of the following applications of cyclodextrins by the development of the synthesis of new monomeric and polymeric cyclodextrin derivatives:

synthesis of polymeric cyclodextrin resins for the design of filters for the absorption of pollutants from waste waters
synthesis of functional cyclodextrin derivatives for the selective transport of pharmaceutical drugs to certain destination in the human body
synthesis of cyclodextrin monomers and polymers for the separation of mixtures of enantiomeric drug molecules
synthesis of fluorescence labelled cyclodextrins for the selective detection of pollutants

II. Indirect Results

development of improved filtering devices
development of new methods for surface modification of polymers by cyclodextrins
improvement of drug formulations

These improvements will be achieved by the close co-operation of an international research team comprising organic chemists, polymeric chemists, pharmacologists, physicochemists and chemists from industry.

Application

The obtained results will be useful for producers of cyclodextrins and pharmaceutical industry. Also it might help small and medium enterprises to produce specialised high value products.

Results to Date

New cyclodextrin-resins for the removal chlorinated phenols from waste water.
New chromatography materials for the separation of enantiomers. Synthesis of new water-soluble cyclodextrin polymers. Development of sensor molecules for steroids.

GPC analysis of a cyclodextrin polymer
at the Polymer-Institute, University of Karlsruhe, Germany

Contacts

Coordinator

Universitat Karlsruhe Polymer Instistut / GERMANY

Participant